The typical day at the office for me is really triage from start to finish. You have to be able to focus on seven different episodes at any given time and keep every detail of every single one totally straight in your head. . . . I’m diving from one room to the other. You can’t imagine the amount of crap that comes on top of it, and what’s amazing, you’ll be on a phone call yelling, being like some Hollywood cliché of a producer--$#%&*@. You tell them they’re going to get $#%&*@. You hang up the phone and you walk into the room and go “OK now let’s get creative.”--Eric Kripke, Creator and Showrunner of Supernatural, "Kripke's Guide to the Apocalypse," extra on Season Five DVD set
See also here and here.